William R Kem Selected Research

3- (4- hydroxy- 2- methoxybenzylidene)anabaseine

1/2021	Therapeutic efficacy of α7 ligands after acute ischaemic stroke is linked to conductive states of α7 nicotinic ACh receptors.
1/2021	Spleen is not required for therapeutic effects of 4OH-GTS-21, a selective α7 nAChR agonist, in the sub-acute phase of ischemic stroke in rats.

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William R Kem Research Topics

Disease

10	Schizophrenia (Dementia Praecox) 01/2023 - 06/2004
4	Burns 12/2022 - 01/2017
4	Inflammation (Inflammations) 01/2021 - 01/2017
3	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 03/2009
2	Pain (Aches) 12/2022 - 01/2021
2	Hyperalgesia 12/2022 - 01/2021
2	Ischemic Stroke 01/2021 - 01/2021
2	Brain Injuries (Brain Injury) 01/2021 - 01/2021
1	Procedural Pain 12/2022
1	Necrosis 12/2022
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2021
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2021
1	Hypertension (High Blood Pressure) 01/2021
1	Neuroinflammatory Diseases 01/2021
1	Atrophic Muscular Disorders 11/2018
1	Cognitive Dysfunction 01/2018
1	Neuroblastoma 01/2018
1	Body Weight (Weight, Body) 01/2017
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/2013
1	Scoliosis 05/2010
1	Torticollis (Wryneck) 05/2010
1	Lordosis 05/2010
1	Cleft Palate (Palate, Cleft) 05/2010
1	Hemolysis 06/2009
1	Contracture 08/2004

Drug/Important Bio-Agent (IBA)

10	3-(2,4-dimethoxybenzylidene)anabaseineIBA 01/2023 - 06/2010
8	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 12/2022 - 06/2004
6	Cholinergic ReceptorsIBA 01/2021 - 03/2010
4	Nicotinic AgonistsIBA 01/2018 - 06/2006
3	alpha7 Nicotinic Acetylcholine ReceptorIBA 01/2023 - 06/2006
3	Nicotine FDA Link 12/2022 - 06/2004
3	salicylhydroxamic acid (SHAM)IBA 12/2022 - 01/2017
2	NF-kappa B (NF-kB)IBA 12/2022 - 01/2021
2	InterleukinsIBA 12/2022 - 01/2021
2	LigandsIBA 01/2021 - 01/2021
2	Therapeutic UsesIBA 01/2021 - 01/2021
2	3- (4- hydroxy- 2- methoxybenzylidene)anabaseineIBA 01/2021 - 01/2021
2	CytokinesIBA 01/2021 - 01/2017
2	Interleukin-6 (Interleukin 6)IBA 01/2021 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2011
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2017
1	anabaseineIBA 01/2023
1	Cholinergic AgonistsIBA 12/2022
1	Opioid Analgesics (Opioids)IBA 12/2022
1	Morphine (MS Contin)FDA LinkGeneric 12/2022
1	Toll-Like Receptor 4IBA 12/2022
1	CalciumIBA 01/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	AutoantibodiesIBA 01/2021
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021
1	1- (5- chloro- 2,4- dimethoxyphenyl)- 3- (5- methylisoxazol- 3- yl)ureaIBA 01/2021
1	methyllycaconitineIBA 01/2021
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2021
1	1,4- diazabicyclo(3.2.2)nonan- 4- yl(5- (3- (trifluoromethyl)phenyl)furan- 2- yl)methanoneIBA 01/2021
1	Phosphotransferases (Kinase)IBA 01/2021
1	MethemoglobinIBA 11/2018
1	Delayed-Action PreparationsIBA 01/2018
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2018
1	Amyloid (Amyloid Fibrils)IBA 01/2018
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	Insulin (Novolin)FDA Link 01/2017
1	poly-APSIBA 07/2013
1	SaltsIBA 07/2013
1	PolymersIBA 07/2013
1	AlkaloidsIBA 05/2010
1	Colloids (Colloid)IBA 06/2009
1	S 24795IBA 03/2009
1	Antipsychotic Agents (Antipsychotics)IBA 06/2006
1	SmokeIBA 06/2006
1	Carbachol (Carbastat)FDA Link 08/2004
1	CarbonIBA 08/2004
1	Cholinergic Agents (Cholinergics)IBA 06/2004
1	gamma-Aminobutyric Acid (GABA)IBA 06/2004

Therapy/Procedure

1	Splenectomy 01/2021